Technology Platform
1. Expression of target proteins
●  Escherichia coli expression system
●  Yeast expression system
●  Mammalian cell expression system
●  Escherichia coli expression system specialized for membrane protein
2. Fine analysis on physical and chemical properties of target protein
●  Circular dichroism
●  Analytical ultracentrifuge
●  Biacore
●  Isothermal titration calorimetry
●  uclear magnetic resonance
●  Dynamic light scattering
3. High-resolution NMR analysis on Physical and Chemical Properties of the target protein
●  Rapid evaluation on protein structures via 1D or 2D 15N-HSQC NMR
●  Detection of weak binding between protein-protein or protein-small molecule interactions
●  Structural determination of protein-bound ligands via STD NMR or transferred NOE
●  Protein dynamics by NMR
●  Measurement of side chain pKa values in proteins
●  Lead compound/drug screening and optimization
4. Identification of target protein
●  Identification of individual protein within protein complexes
●  Identification of protein post-translational modifications
●  Whole-proteomic sequencing of antibody or drug target(s)
●  Glycome analysis of protein glycosylation
●  Quantitative analysis of protein post-translational modification
5. 3D structural analysis of target protein
●  Protein X-ray crystallography
●  Nuclear Magnetic Resonance Spectroscopy (NMR)
●  Cryo-electron microscopy (Cryo-EM)
●  Small-angle X-ray scattering (SAXS)
6. Experimental structure-based protein engineering and drug design
●  Structure-based design and optimization of small-molecule drug
●  Structure-based protein engineering
●  Structure-based antibody engineering
7. Computer-aided drug design and systems biology
●  Virtual screening
●  Molecular docking
●  Bioinformatics analysis
●  Structure-based systems biology analysis
●  High-throughput bioanalysis
●  Biological network analysis
8. Advance proteomics analysis
●  High-performance proteomic/phosphoproteomic/glycoproteomic profiling platform
●  Personalized proteomics analysis of clinical specimens
●  Multiplexed protein quantification by multiple reaction monitoring

Contact: Ms. Ming-Yi Lin
No. 128 Academia Road, Section 2, Nankang, Taipei 11529, Taiwan   Tel : 886-2-27855696 #3040
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